Cystic Fibrosis and New Trends by Ophthalmological Evaluation : A Pilot Study
Joint Authors
Leggieri, Emanuela
Spadea, Leopoldo
Quattrucci, Serena
Vingolo, Enzo Maria
Nebbioso, Marcella
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Cystic fibrosis (CF) is characterized by hypoxia that affects several organic tissues.
Retinal ganglion cells may suffer from the hypoxic status, and this may lead to alterations of retinal nerve fiber.
Methods.
Twenty-two eyes in CF patients were analyzed.
A complete ocular evaluation and visual field exams of the 30 central degrees were performed using the frequency doubling technology (FDT).
Forced expiratory volume in one second (FEV1%), forced vital capacity (FVC%), oxyhaemoglobin saturation (SpO2%), and hematocrit (Ht%) have been calculated.
FDT analyzed parameters were mean deviation (MD) and pattern standard deviation (PSD).
Pearson’s correlation was chosen as statistical analysis.
Results.
Data showed statistically significant relationship between MD and Ht% (r value −0.18; P=0.04), MD and FEV1% (r value −0.68; P=0.001), and MD and FVC% (r value −0.45; P=0.005).
Moreover, there were correlations between PSD and Ht% (r value 0.29; P=0.03), PSD and SpO2% (r value −0.31; P=0.01), PSD and FEV1% (r value 0.71; P=0.0005), and PSD and FVC% (r value 0.63; P=0.003).
Conclusions.
The oxygen supply alterations might determine hypoxia of the ganglion cells causing a decrease of receptive optic nerve fiber activity.
This method could be also useful to evaluate indirectly pulmonary activity of the CF disease.
American Psychological Association (APA)
Nebbioso, Marcella& Quattrucci, Serena& Leggieri, Emanuela& Spadea, Leopoldo& Vingolo, Enzo Maria. 2014. Cystic Fibrosis and New Trends by Ophthalmological Evaluation : A Pilot Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482390
Modern Language Association (MLA)
Nebbioso, Marcella…[et al.]. Cystic Fibrosis and New Trends by Ophthalmological Evaluation : A Pilot Study. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-482390
American Medical Association (AMA)
Nebbioso, Marcella& Quattrucci, Serena& Leggieri, Emanuela& Spadea, Leopoldo& Vingolo, Enzo Maria. Cystic Fibrosis and New Trends by Ophthalmological Evaluation : A Pilot Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-482390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482390