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Improvement of Radiation-Mediated Immunosuppression of Human NSCLC Tumour Xenografts in a Nude Rat Model
Joint Authors
Tokalov, Sergey V.
Abolmaali, Nasreddin
Enghardt, Wolfgang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Human tumour xenografts in a nude rat model have consistently been used as an essential part of preclinical studies for anticancer drugs activity in human.
Commonly, these animals receive whole body irradiation to assure immunosuppression.
But whole body dose delivery might be inhomogeneous and the resulting incomplete bone marrow depletion may modify tumour behaviour.
To improve irradiation-mediated immunosuppression of human non-small cell lung cancer (NSCLC) xenografts in a nude rat model irradiation (2 + 2 Gy) from opposite sides of animals has been performed using a conventional X-ray tube.
The described modification of whole body irradiation improves growth properties of human NSCLC xenografts in a nude rat model.
The design of the whole body irradiation mediated immunosuppression described here for NSCLC xenografts may be useful for research applications involving other types of human tumours.
American Psychological Association (APA)
Tokalov, Sergey V.& Enghardt, Wolfgang& Abolmaali, Nasreddin. 2010. Improvement of Radiation-Mediated Immunosuppression of Human NSCLC Tumour Xenografts in a Nude Rat Model. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-482408
Modern Language Association (MLA)
Tokalov, Sergey V.…[et al.]. Improvement of Radiation-Mediated Immunosuppression of Human NSCLC Tumour Xenografts in a Nude Rat Model. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-482408
American Medical Association (AMA)
Tokalov, Sergey V.& Enghardt, Wolfgang& Abolmaali, Nasreddin. Improvement of Radiation-Mediated Immunosuppression of Human NSCLC Tumour Xenografts in a Nude Rat Model. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-482408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482408