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Pituitary Adenoma Nitroproteomics : Current Status and Perspectives
Joint Authors
Zhan, Xianquan
Desiderio, Dominic M.
Wang, Xiaowei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Oxidative stress is extensively associated with tumorigenesis.
A series of studies on stable tyrosine nitration as a marker of oxidative damage were performed in human pituitary and adenoma.
This paper reviews published research on the mass spectrometry characteristics of nitropeptides and nitroproteomics of pituitary controls and adenomas.
The methodology used for nitroproteomics, the current status of human pituitary nitroproteomics studies, and the future perspectives are reviewed.
Enrichment of those low-abundance endogenous nitroproteins from human tissues or body fluid samples is the first important step for nitroproteomics studies.
Mass spectrometry is the essential approach to determine the amino acid sequence and locate the nitrotyrosine sites.
Bioinformatics analyses, including protein domain and motif analyses, are needed to locate the nitrotyrosine site within the corresponding protein domains/motifs.
Systems biology techniques, including pathway analysis, are necessary to discover signaling pathway networks involving nitroproteins from the systematically global point of view.
Future quantitative nitroproteomics will discover pituitary adenoma-specific nitroprotein(s).
Structural biology techniques such as X-ray crystallography analysis will solidly clarify the effects of tyrosine nitration on structure and functions of a protein.
Those studies will eventually address the mechanisms and biological functions of tyrosine nitration in pituitary tumorigenesis and will discover nitroprotein biomarkers for pituitary adenomas and targets for drug design for pituitary adenoma therapy.
American Psychological Association (APA)
Zhan, Xianquan& Wang, Xiaowei& Desiderio, Dominic M.. 2013. Pituitary Adenoma Nitroproteomics : Current Status and Perspectives. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-482428
Modern Language Association (MLA)
Zhan, Xianquan…[et al.]. Pituitary Adenoma Nitroproteomics : Current Status and Perspectives. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-482428
American Medical Association (AMA)
Zhan, Xianquan& Wang, Xiaowei& Desiderio, Dominic M.. Pituitary Adenoma Nitroproteomics : Current Status and Perspectives. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-482428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482428