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Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template
Joint Authors
Windhorst, Albert D.
Fisher, Abraham
Buiter, Hans J. C.
Leysen, Josée E.
van Velden, Floris H. P.
Huisman, Marc C.
Lammertsma, Adriaan Anthonius
Source
International Journal of Molecular Imaging
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
An important step in the analysis of positron emission tomography (PET) studies of the brain is the definition of regions of interest (ROI).
Image coregistration, ROI analysis, and quantification of brain PET data in small animals can be observer dependent.
The purpose of this study was to investigate the feasibility of ROI analysis based on a standard MR template and an additional [18F]NaF scan.
Methods.
[18F]NaF scans of 10 Wistar rats were coregistered with a standard MR template by 3 observers and derived transformation matrices were applied to corresponding [11C]AF150(S) images.
Uptake measures were derived for several brain regions delineated using the MR template.
Overall agreement between the 3 observers was assessed by interclass correlation coefficients (ICC) of uptake data.
In addition, [11C]AF150(S) ROI data were compared with ex vivo biodistribution data.
Results.
For all brain regions, ICC analysis showed excellent agreement between observers.
Reproducibility, estimated by calculation of standard deviation of the between-observer differences, was demonstrated by an average of 17% expressed as coefficient of variation.
Uptake of [11C]AF150(S) derived from ROI analysis closely matched ex vivo biodistribution data.
Conclusions.
The proposed method provides a reproducible and tracer-independent method for ROI analysis of rat brain PET data.
American Psychological Association (APA)
Buiter, Hans J. C.& van Velden, Floris H. P.& Leysen, Josée E.& Fisher, Abraham& Windhorst, Albert D.& Lammertsma, Adriaan Anthonius…[et al.]. 2012. Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template. International Journal of Molecular Imaging،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-482429
Modern Language Association (MLA)
Buiter, Hans J. C.…[et al.]. Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template. International Journal of Molecular Imaging No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-482429
American Medical Association (AMA)
Buiter, Hans J. C.& van Velden, Floris H. P.& Leysen, Josée E.& Fisher, Abraham& Windhorst, Albert D.& Lammertsma, Adriaan Anthonius…[et al.]. Reproducible Analysis of Rat Brain PET Studies Using an Additional [18F]NaF Scan and an MR-Based ROI Template. International Journal of Molecular Imaging. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-482429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482429