Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease
Joint Authors
Umehara, Hisanori
Yamada, Kazunori
Sugiura, Tomoko
Eguchi, Katumi
Azumi, Atsushi
Nakajima, Akio
Umeda, Naoto
Kurose, Nozomu
Sawaki, Toshioki
Masaki, Yasufumi
Iwao, Haruka
Nakamura, Takuji
Takahashi, Hiroki
Saeki, Takako
Nakada, Shinji
Miki, Miyuki
Kawanami, Takafumi
Sugai, Susumu
Horikoshi, Masanobu
Matsui, Shoko
Fujikawa, Keita
Fujita, Yoshimasa
Origuchi, Tomoki
Yamamoto, Motohisa
Kawano, Mitsuhiro
Hirabayashi, Akira
Nishiyama, Susumu
Sakai, Tomoyuki
Tanaka, Masao
Fukushima, Toshihiro
Minato, Hiroshi
Source
International Journal of Rheumatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
IgG4-related disease is a new disease classification established in Japan in the 21st century.
Patients with IgG4-related disease display hyper-IgG4-gammaglobulinemia, massive infiltration of IgG4+ plasma cells into tissue, and good response to glucocorticoids.
Since IgG4 overexpression is also observed in other disorders, it is necessary to diagnose IgG4-related disease carefully and correctly.
We therefore sought to determine cutoff values for serum IgG4 and IgG4/IgG and for IgG4+/IgG+ plasma cells in tissue diagnostic of IgG4-related disease.
Patients and Methods.
We retrospectively analyzed serum IgG4 concentrations and IgG4/IgG ratio and IgG4+/IgG+ plasma cell ratio in tissues of 132 patients with IgG4-related disease and 48 patients with other disorders.
Result.
Serum IgG4 >135 mg/dl demonstrated a sensitivity of 97.0% and a specificity of 79.6% in diagnosing IgG4-related disease, and serum IgG4/IgG ratios >8% had a sensitivity and specificity of 95.5% and 87.5%, respectively.
IgG4+cell/IgG+ cell ratio in tissues >40% had a sensitivity and specificity of 94.4% and 85.7%, respectively.
However, the number of IgG4+ cells was reduced in severely fibrotic parts of tissues.
Conclusion.
Although a recent unanimous consensus of all relevant researchers in Japan recently established the diagnostic criteria for IgG4-related disease, findings such as ours indicate that further discussion is needed.
American Psychological Association (APA)
Masaki, Yasufumi& Kurose, Nozomu& Yamamoto, Motohisa& Takahashi, Hiroki& Saeki, Takako& Azumi, Atsushi…[et al.]. 2012. Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482444
Modern Language Association (MLA)
Masaki, Yasufumi…[et al.]. Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. International Journal of Rheumatology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-482444
American Medical Association (AMA)
Masaki, Yasufumi& Kurose, Nozomu& Yamamoto, Motohisa& Takahashi, Hiroki& Saeki, Takako& Azumi, Atsushi…[et al.]. Cutoff Values of Serum IgG4 and Histopathological IgG4+ Plasma Cells for Diagnosis of Patients with IgG4-Related Disease. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-482444
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482444