Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity
Joint Authors
Barbara, J.
Abuaf, N.
Mathelier-Fusade, P.
Francès, C.
Girot, Robert
Rostane, H.
Gaouar, H.
Toly-Ndour, C.
Leynadier, F.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
An in vitro basophil activation test, based on the detection of CD63 upregulation induced by NSAIDs, has been described.
Its clinical significance remains controversial.
Objectives.
In patients with a history of nonallergic NSAID hypersensitivity, stratified according to the severity of the symptoms, to assess with NSAIDs the predictive value of basophil (BAT) and monocyte (MAT) activation tests.
Patients/Methods.
Sixty patients who had NSAIDs-induced or exacerbated urticaria/angiooedema and 20 controls was included.
After incubation with NSAIDs or acetaminophen, leukocytes were analysed for CD63 upregulation.
Results.
With aspirin, the sensitivity (37%) and specificity (90%) of BAT agree with already published results.
In contrast, when patients had had cutaneous and visceral reactions, the frequency of positive BAT 14/22 (64%, P<0.001) or MAT 10/22 (46%, P<0.01) were increased.
Conclusions.
Positive tests were more frequent among patients having a severe hypersensitivity contrasting with the other patients who had results similar to controls.
American Psychological Association (APA)
Abuaf, N.& Rostane, H.& Barbara, J.& Toly-Ndour, C.& Gaouar, H.& Mathelier-Fusade, P.…[et al.]. 2011. Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity. Journal of Allergy،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482455
Modern Language Association (MLA)
Abuaf, N.…[et al.]. Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity. Journal of Allergy No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482455
American Medical Association (AMA)
Abuaf, N.& Rostane, H.& Barbara, J.& Toly-Ndour, C.& Gaouar, H.& Mathelier-Fusade, P.…[et al.]. Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity. Journal of Allergy. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482455