Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation : The Curious Case of HIV-1
Author
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-22
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Type I interferon (IFN-I) play a critical role in the innate immune response against viral infections.
They actively participate in antiviral immunity by inducing molecular mechanisms of viral restriction and by limiting the spread of the infection, but they also orchestrate the initial phases of the adaptive immune response and influence the quality of T cell immunity.
During infection with the human immunodeficiency virus type 1 (HIV-1), the production of and response to IFN-I may be severely altered by the lymphotropic nature of the virus.
In this review I consider the different aspects of virus sensing, IFN-I production, signalling, and effects on target cells, with a particular focus on the alterations observed following HIV-1 infection.
American Psychological Association (APA)
Boasso, Adriano. 2013. Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation : The Curious Case of HIV-1. Scientifica،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-482462
Modern Language Association (MLA)
Boasso, Adriano. Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation : The Curious Case of HIV-1. Scientifica No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-482462
American Medical Association (AMA)
Boasso, Adriano. Type I Interferon at the Interface of Antiviral Immunity and Immune Regulation : The Curious Case of HIV-1. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-482462
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482462