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Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management
Joint Authors
Seeber, Laura M. S.
Zweemer, Ronald P.
van Diest, Paul J.
Verheijen, René H. M.
Source
Obstetrics and Gynecology International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the Western world, endometrial cancer (EC) is the most common malignant tumor of the female genital tract.
Solid tumors like EC outgrow their vasculature resulting in hypoxia.
Tumor hypoxia is important because it renders an aggressive phenotype and leads to radio- and chemo-therapy resistance.
Hypoxia-inducible factor-1α (HIF-1α) plays an essential role in the adaptive cellular response to hypoxia and is associated with poor clinical outcome in EC.
Therefore, HIF-1 could be an attractive therapeutic target.
Selective HIF-1 inhibitors have not been identified.
A number of nonselective inhibitors which target signaling pathways upstream or downstream HIF-1 are known to decrease HIF-1α protein levels.
In clinical trials for the treatment of advanced and/or recurrent EC are the topoisomerase I inhibitor Topotecan, mTOR-inhibitor Rapamycin, and angiogenesis inhibitor Bevacizumab.
Preliminary data shows encouraging results for these agents.
Further work is needed to identify selective HIF-1 inhibitors and to translate these into clinical trials.
American Psychological Association (APA)
Seeber, Laura M. S.& Zweemer, Ronald P.& Verheijen, René H. M.& van Diest, Paul J.. 2010. Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management. Obstetrics and Gynecology International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-482463
Modern Language Association (MLA)
Seeber, Laura M. S.…[et al.]. Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management. Obstetrics and Gynecology International No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-482463
American Medical Association (AMA)
Seeber, Laura M. S.& Zweemer, Ronald P.& Verheijen, René H. M.& van Diest, Paul J.. Hypoxia-Inducible Factor-1 as a Therapeutic Target in Endometrial Cancer Management. Obstetrics and Gynecology International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-482463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482463