Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations
Joint Authors
Zenita, O.
Basavaiah, Kanakapura
Source
International Journal of Analytical Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Two titrimetric and two spectrophotometric methods are described for the assay of famotidine (FMT) in tablets using N-bromosuccinimide (NBS).
The first titrimetric method is direct in which FMT is titrated directly with NBS in HCl medium using methyl orange as indicator (method A).
The remaining three methods are indirect in which the unreacted NBS is determined after the complete reaction between FMT and NBS by iodometric back titration (method B) or by reacting with a fixed amount of either indigo carmine (method C) or neutral red (method D).
The method A and method B are applicable over the range of 2–9 mg and 1–7 mg, respectively.
In spectrophotometric methods, Beer's law is obeyed over the concentration ranges of 0.75–6.0 μg mL-1 (method C) and 0.3–3.0 μg mL-1 (method D).
The applicability of the developed methods was demonstrated by the determination of FMT in pure drug as well as in tablets.
American Psychological Association (APA)
Zenita, O.& Basavaiah, Kanakapura. 2011. Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations. International Journal of Analytical Chemistry،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-482491
Modern Language Association (MLA)
Zenita, O.& Basavaiah, Kanakapura. Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations. International Journal of Analytical Chemistry No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-482491
American Medical Association (AMA)
Zenita, O.& Basavaiah, Kanakapura. Utility of N-Bromosuccinimide for the Titrimetric and Spectrophotometric Determination of Famotidine in Pharmaceutical Formulations. International Journal of Analytical Chemistry. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-482491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482491