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Cost Effectiveness of TNF-α Inhibitors in Rheumatoid Arthritis
Joint Authors
Serracino Inglott, Anthony
Coleiro, Bernard
Said, Cynthia
Zarb Adami, Maurice
Azzopardi, Lilian M.
Source
International Journal of Inflammation
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
TNF-α inhibitors have shown to be effective in reducing disease activity and improving the quality of life.
Due to the high costs associated with acquisition of this treatment, this study was undertaken to evaluate the ICER of TNF-α antagonists (etanercept, adalimumab, and infliximab) in improving the quality of life.
Methods.
The HAQ and SF-36 were administered at phases 1, 2, and 3, in order to assess the improvement in the QOL.
Suppression of disease activity was assessed through the DAS-28.
Results.
Statistically significant improvements (P<0.05) were noted for the SF-36 and HAQ after 3 months and for the DAS-28 after 6 months of TNF-α inhibitor therapy.
The mean ICER per 10% improvement in the HAQ, DAS-28, and SF-6D were €1976.5, €2086.5, and €2316.4, respectively, following 6 months of TNF-α intervention.
Most favorable ICERs were reported from a patient who had to undergo surgical intervention whilst on DMARD therapy.
Conclusion.
Significant improvement was observed in patients’ quality of life, after a short timeframe of 6 months.
Such data is useful information in the light of convincing policy makers, in terms of providing access to the medications to individual patients on national health service schemes.
American Psychological Association (APA)
Said, Cynthia& Coleiro, Bernard& Zarb Adami, Maurice& Azzopardi, Lilian M.& Serracino Inglott, Anthony. 2013. Cost Effectiveness of TNF-α Inhibitors in Rheumatoid Arthritis. International Journal of Inflammation،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482496
Modern Language Association (MLA)
Said, Cynthia…[et al.]. Cost Effectiveness of TNF-α Inhibitors in Rheumatoid Arthritis. International Journal of Inflammation No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-482496
American Medical Association (AMA)
Said, Cynthia& Coleiro, Bernard& Zarb Adami, Maurice& Azzopardi, Lilian M.& Serracino Inglott, Anthony. Cost Effectiveness of TNF-α Inhibitors in Rheumatoid Arthritis. International Journal of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-482496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482496