Renal Transplantation in Hepatitis C Positive Patients : A Single Centre Experience
Joint Authors
Patel, H. V.
Vanikar, Aruna V.
Shah, Pankaj R.
Gumber, M. R.
Trivedi, Hargovind L.
Kute, Vivek B.
Godara, S. M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Introduction.
Hepatitis C virus (HCV) infection is an independent risk factor for renal transplantation (RTx).
Immunosuppression minimization can render better quality of life to these patients.
Methods.
We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs.
TIP consisted of 1 donor-specific transfusion, peripheral blood stem cell infusion, portal infusion of bone marrow, and target-specific irradiation.
Their immunosuppression was cyclosporin, 2 ± 1 mg/kg BW/day + prednisone, 10 mg/day.
Results.
TIP had no side effects.
Although unequal in size, the groups were well balanced.
Group A patient survival at 1, 5, and 10 years was 92.4%, 70.4%, and 63.7%, respectively, versus 75.6%, 71.7%, and 55.7% in later, and graft survival was 92.9%, 81.5%, and 79.1% versus 91.7%, 75.7%, and 67.7%, respectively.
Mean serum creatinine (mg/dL) at these time periods in former was 1.38, 1.72, and 1.87, versus 1.3, 1.75, and 2.1 in later.
Altered liver functions were noted in 22% patients in former versus 31% in later.
Group A had lesser rejection episodes.
Conclusion.
RTx using TIP in HCV-positive patients is a viable option with acceptable outcome.
American Psychological Association (APA)
Shah, Pankaj R.& Vanikar, Aruna V.& Gumber, M. R.& Patel, H. V.& Kute, Vivek B.& Godara, S. M.…[et al.]. 2011. Renal Transplantation in Hepatitis C Positive Patients : A Single Centre Experience. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-482505
Modern Language Association (MLA)
Shah, Pankaj R.…[et al.]. Renal Transplantation in Hepatitis C Positive Patients : A Single Centre Experience. Journal of Transplantation No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-482505
American Medical Association (AMA)
Shah, Pankaj R.& Vanikar, Aruna V.& Gumber, M. R.& Patel, H. V.& Kute, Vivek B.& Godara, S. M.…[et al.]. Renal Transplantation in Hepatitis C Positive Patients : A Single Centre Experience. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-482505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482505