![](/images/graphics-bg.png)
Matrix Metalloproteinases and Bladder Cancer : What is New?
Joint Authors
Eiró, N.
Fernández-Gómez, J. M.
Algaba, F.
Rodriguez Faba, O.
Villavicencio-Mavrich, H.
Vizoso, F. J.
Palou-Redorta, J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Urothelial bladder cancer represents a heterogeneous disease with divergent pathways of tumorigenesis.
Tumor invasion and progression are a multifactorial process promoted by microenvironmental changes that include overexpression of matrix metalloproteinases (MMPs).
Recent data clearly challenge the classic dogma that MMPs promote metastasis only by modulating the remodeling of extracellular matrix.
Indeed, MMPs have also been attributed as an impact on tumor cell behavior in vivo as a consequence of their ability to cleave growth factors, cell surface receptors, cell adhesion molecules, and chemokines/cytokines.
Levels of the different MMPs can be measured in several sample types, including tissue, blood (serum and plasma), and urine, and using different methodologies, such as immunohistochemistry, real-time PCR, western and northern blot analyses, enzyme-linked immunosorbent assay, and zymography.
Several MMPs have been identified as having potential diagnostic or prognostic utility, whether alone or in combination with cytology.
Although MMP inhibitors have shown limited efficacy, advances in the understanding of the complex physiologic and pathologic roles of MMPs might permit the development of new MMP-specific and tumor-specific therapies.
In this paper we update the understanding of MMPs based on a systematic PubMed search encompassing papers published up to December 2011.
American Psychological Association (APA)
Rodriguez Faba, O.& Palou-Redorta, J.& Fernández-Gómez, J. M.& Algaba, F.& Eiró, N.& Villavicencio-Mavrich, H.…[et al.]. 2012. Matrix Metalloproteinases and Bladder Cancer : What is New?. ISRN Urology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482511
Modern Language Association (MLA)
Rodriguez Faba, O.…[et al.]. Matrix Metalloproteinases and Bladder Cancer : What is New?. ISRN Urology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-482511
American Medical Association (AMA)
Rodriguez Faba, O.& Palou-Redorta, J.& Fernández-Gómez, J. M.& Algaba, F.& Eiró, N.& Villavicencio-Mavrich, H.…[et al.]. Matrix Metalloproteinases and Bladder Cancer : What is New?. ISRN Urology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-482511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482511