Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction
Joint Authors
Ishida, Susumu
Tsubota, Kazuo
Okano, Hideyuki
Ozawa, Yoko
Kurihara, Toshihide
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The renin-angiotensin system (RAS) is a hormone system that has been classically known as a blood pressure regulator but is becoming well recognized as a proinflammatory mediator.
In many diverse tissues, RAS pathway elements are also produced intrinsically, making it possible for tissues to respond more dynamically to systemic or local cues.
While RAS is important for controlling normal inflammatory responses, hyperactivation of the pathway can cause neural dysfunction by inducing accelerated degradation of some neuronal proteins such as synaptophysin and by activating pathological glial responses.
Chronic inflammation and oxidative stress are risk factors for high incidence vision-threatening diseases such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and glaucoma.
In fact, increasing evidence suggests that RAS inhibition may actually prevent progression of various ocular diseases including uveitis, DR, AMD, and glaucoma.
Therefore, RAS inhibition may be a promising therapeutic approach to fine-tune inflammatory responses and to prevent or treat certain ocular and neurodegenerative diseases.
American Psychological Association (APA)
Kurihara, Toshihide& Ozawa, Yoko& Ishida, Susumu& Okano, Hideyuki& Tsubota, Kazuo. 2012. Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-482525
Modern Language Association (MLA)
Kurihara, Toshihide…[et al.]. Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction. International Journal of Inflammation No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-482525
American Medical Association (AMA)
Kurihara, Toshihide& Ozawa, Yoko& Ishida, Susumu& Okano, Hideyuki& Tsubota, Kazuo. Renin-Angiotensin System Hyperactivation Can Induce Inflammation and Retinal Neural Dysfunction. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-482525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482525