Toll-Like Receptors, Tissue Injury, and Tumourigenesis
Joint Authors
Ioannou, Savvas
Voulgarelis, Michael
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Toll-like receptors (TLRs) belong to a class of molecules known as pattern recognition receptors, and they are part of the innate immune system, although they modulate mechanisms that impact the development of adaptive immune responses.
Several studies have shown that TLRs, and their intracellular signalling components, constitute an important cellular pathway mediating the inflammatory process.
Moreover, their critical role in the regulation of tissue injury and wound healing process as well as in the regulation of apoptosis is well established.
However, interest in the role of these receptors in cancer development and progression has been increasing over the last years.
TLRs are likely candidates to mediate effects of the innate immune system within the tumour microenvironment.
A rapidly expanding area of research regarding the expression and function of TLRs in cancer cells and its association with chemoresistance and tumourigenesis, and TLR-based therapy as potential immunotherapy in cancer treatment is taking place over the last years.
American Psychological Association (APA)
Ioannou, Savvas& Voulgarelis, Michael. 2010. Toll-Like Receptors, Tissue Injury, and Tumourigenesis. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-482538
Modern Language Association (MLA)
Ioannou, Savvas& Voulgarelis, Michael. Toll-Like Receptors, Tissue Injury, and Tumourigenesis. Mediators of Inflammation No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-482538
American Medical Association (AMA)
Ioannou, Savvas& Voulgarelis, Michael. Toll-Like Receptors, Tissue Injury, and Tumourigenesis. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-482538
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482538