Antimicrobial Activity of Coronarin D and Its Synergistic Potential with Antibiotics

Abstract EN

Coronarin D is a labdane-type diterpene from the rhizomes of Hedychium coronarium.

In the view of our ongoing effort to explore its novel biological activity, antimicrobial activity study of coronarin D was performed.

The results showed that coronarin D was active against tested Gram-positive bacteria, inactive for tested Gram-negative bacteria, and weakly active against tested fungi.

The antibacterial effect of the combination of coronarin D with nine classical antibiotics against four Gram-positive bacteria was also evaluated.

The fractional inhibitory concentration indices (FICI) of coronarin D-antibiotics combinations, calculated from the checkerboard assay, were used as synergism indicator.

Out of 36 combinations, 47% showed total synergism, 33% had partial synergistic interaction, 17% showed no effect, and 3% showed antagonism.

By combination with coronarin D at concentration of 0.25 minimal inhibitory concentration (MIC), the activities of antibiotics were boosted to 4- to 128-fold.

These finding suggested an attractive approach to combat the infectious diseases by using coronarin D-antibiotic drug combination.