Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease
Joint Authors
Ofori-Acquah, Solomon F.
Tan, Fang
Ghosh, Samit
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Sickle cell disease (SCD) is characterized by chronic intravascular hemolysis that generates excess cell-free hemoglobin in the blood circulation.
Hemoglobin causes multiple endothelial dysfunctions including increased vascular permeability, impaired reactivity to vasoactive agonists, and increased adhesion of leukocytes to the endothelium.
While the adhesive and vasomotor defects of SCD associated with cell-free hemoglobin are well defined, the vascular permeability phenotype remains poorly appreciated.
We addressed this issue in two widely used and clinically relevant mouse models of SCD.
We discovered that the endothelial barrier is normal in most organs in the young but deteriorates with aging particularly in the lung.
Indeed, middle-aged sickle mice developed pulmonary edema revealing for the first time similarities in the chronic permeability phenotypes of the lung in mice and humans with SCD.
Intravenous administration of lysed red blood cells into the circulation of sickle mice increased vascular permeability significantly in the lung without impacting permeability in other organs.
Thus, increased vascular permeability is an endothelial dysfunction of SCD with the barrier in the lung likely the most vulnerable to acute inflammation.
American Psychological Association (APA)
Ghosh, Samit& Tan, Fang& Ofori-Acquah, Solomon F.. 2012. Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease. Anemia،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482554
Modern Language Association (MLA)
Ghosh, Samit…[et al.]. Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease. Anemia No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-482554
American Medical Association (AMA)
Ghosh, Samit& Tan, Fang& Ofori-Acquah, Solomon F.. Spatiotemporal Dysfunction of the Vascular Permeability Barrier in Transgenic Mice with Sickle Cell Disease. Anemia. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482554
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482554