A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS : Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression
Joint Authors
Bowser, Robert
Hank, Nicole C.
Stephan, Dietrich
Saperstein, David S.
Van Keuren-Jensen, Kendall
Levine, Todd D.
Gately, Stephen
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
To determine if therapy with pioglitazone HCl and tretinoin could slow disease progression in patients with ALS.
Levels of tau and pNFH in the cerebrospinal fluid were measured to see if they could serve as prognostic indicators.
Methods.
27 subjects on stable doses of riluzole were enrolled.
Subjects were randomized to receive pioglitazone 30 mg/d and tretinoin 10 mg/BID for six months or two matching placebos.
ALSFRS-R scores were followed monthly.
At baseline and at the final visit, lumbar punctures (LPs) were performed to measure cerebrospinal fluid (CSF) biomarker levels.
Results.
Subjects treated with tretinoin, pioglitazone, and riluzole had an average rate of decline on the ALSFRS-R scale of −1.02 points per month; subjects treated with placebo and riluzole had a rate of decline of -.86 (P=.18).
Over six months of therapy, CSF tau levels decreased in subjects randomized to active treatment and increased in subjects on placebo.
Further higher levels of pNF-H at baseline correlated with a faster rate of progression.
Conclusion.
ALS patients who were treated with tretinoin and pioglitazone demonstrated no slowing on their disease progression.
Interestingly, the rate of disease progression was strongly correlated with levels of pNFH in the CSF at baseline.
American Psychological Association (APA)
Levine, Todd D.& Bowser, Robert& Hank, Nicole C.& Gately, Stephen& Stephan, Dietrich& Saperstein, David S.…[et al.]. 2012. A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS : Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression. Neurology Research International،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482560
Modern Language Association (MLA)
Levine, Todd D.…[et al.]. A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS : Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression. Neurology Research International No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-482560
American Medical Association (AMA)
Levine, Todd D.& Bowser, Robert& Hank, Nicole C.& Gately, Stephen& Stephan, Dietrich& Saperstein, David S.…[et al.]. A Pilot Trial of Pioglitazone HCl and Tretinoin in ALS : Cerebrospinal Fluid Biomarkers to Monitor Drug Efficacy and Predict Rate of Disease Progression. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482560