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Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives
Joint Authors
Batra, Rameshkumar J.
Chopde, Himani N.
Meshram, Ekta M.
Pandhurnekar, Chandrashekhar P.
Source
Organic Chemistry International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
With the aim of synthesizing new heterocyclic compounds and exploring biological potency, new series of chalcones, that is, 3-(2-hydroxy-5-(aryl-diazenyl)phenyl)-1-(aryl)prop-2-en-1-one and their pyrimidine derivatives, that is, 4-(2-hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols were synthesized using different aromatic amines and salicylaldehyde as starting moieties.
The structures of newly synthesized compounds were confirmed using different spectroscopic techniques such as IR, 1H-NMR, 13C-NMR, and mass spectral analysis, and elemental analysis.
The newly synthesized pyrimidines derivatives were screened for their in vitro antibacterial and antifungal activities.
It was observed that some of the newly synthesized compounds had shown promising activity against several bacterial and fungal stains.
Anti-bacterial activity and anti-fungal activity studies revealed that pyrimidine derivatives consisting of nitro group in their molecular structure possess better activity than their corresponding chalcones.
American Psychological Association (APA)
Pandhurnekar, Chandrashekhar P.& Meshram, Ekta M.& Chopde, Himani N.& Batra, Rameshkumar J.. 2013. Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives. Organic Chemistry International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-482561
Modern Language Association (MLA)
Pandhurnekar, Chandrashekhar P.…[et al.]. Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives. Organic Chemistry International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-482561
American Medical Association (AMA)
Pandhurnekar, Chandrashekhar P.& Meshram, Ekta M.& Chopde, Himani N.& Batra, Rameshkumar J.. Synthesis, Characterization, and Biological Activity of 4-(2-Hydroxy-5-(aryl-diazenyl)phenyl)-6-(aryl)pyrimidin-2-ols Derivatives. Organic Chemistry International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-482561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482561