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Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs
Joint Authors
Lawson, Charles F.
Mize, Amy
Liu, Jason
Doolittle, Dannette
Rickert, Douglas E.
Richard, Brigitte M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
We explored the potential for EXPAREL to interact with lidocaine.
Sixty (60) male Yucatan Swine were randomized into 20 groups (N=3/group).
EXPAREL (2 or 4 mg/kg) and/or lidocaine HCl solution 1% or 2% (with epinephrine 1 : 200,000) were injected subcutaneously along a 5 cm virtual incision line.
The effects on the pharmacokinetics of bupivacaine and lidocaine were examined when 5, 10, 20, and 40 minutes had passed between administration of lidocaine and EXPAREL.
Systemic exposure to lidocaine was increased (AUC0−24 hr by 48%; Cmax by 1,640%) when lidocaine (4 mg/kg) was followed 5 minutes later by EXPAREL (4 mg/kg) compared to lidocaine administered alone.
Plasma bupivacaine was increased (AUC0−24 hr by 50–95%; Cmax by 67–1,000%) when lidocaine (4 mg/kg) was followed 5 or 10 minutes later by EXPAREL (4 mg/kg) compared to EXPAREL alone.
While EXPAREL should not be admixed with lidocaine, this study shows that local administration of EXPAREL after at least 20 minutes following local administration of lidocaine did not increase the release of either drug.
American Psychological Association (APA)
Richard, Brigitte M.& Rickert, Douglas E.& Doolittle, Dannette& Mize, Amy& Liu, Jason& Lawson, Charles F.. 2011. Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs. ISRN Pharmaceutics،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482576
Modern Language Association (MLA)
Richard, Brigitte M.…[et al.]. Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs. ISRN Pharmaceutics No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-482576
American Medical Association (AMA)
Richard, Brigitte M.& Rickert, Douglas E.& Doolittle, Dannette& Mize, Amy& Liu, Jason& Lawson, Charles F.. Pharmacokinetic Compatibility Study of Lidocaine with EXPAREL in Yucatan Miniature Pigs. ISRN Pharmaceutics. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482576
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482576