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Genetic Dissection of Complex Genetic Factor Involved in NIDDM of OLETF Rat
Joint Authors
Matsumoto, Kozo
Kose, Hiroyuki
Yamada, Takahisa
Ohta, Takeshi
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat is an animal model for obese-type, noninsulin-dependent diabetes mellitus (NIDDM) in humans.
NIDDM in this rat model was shown to be regulated by multiple genes.
We have identified 14 quantitative trait loci (QTLs) responsible for NIDDM (Nidd1-14/of) on chromosomes 1, 5, 7, 8, 9, 11, 12, 14, 16, and 17 by a whole genome search in 160 F2 progenies obtained by mating the OLETF and the F344 rats.
Among these loci, two QTLs, Nidd1 and 2/of, were declared significant loci at a genome-wide level.
Nidd3, 8, 9, and 13/of exhibited heterosis: heterozygotes showing significantly higher glucose levels than OLETF or F344 homozygotes.
We also found evidence for interaction (epistasis) between Nidd1/of and Nidd2/of, between Nidd1/of and Nidd10/of, between Nidd2/of and Nidd8/of, and between Nidd2/of and Nidd14/of.
Furthermore, Nidd6 and 11/of showed linkage with body weight, and Nidd1, 2, 8, 9, 10, and 12/of had an interaction with body weight.
These indicated that NIDDM in the OLETF would have a higher degree of genetic complexity.
We suggest several interesting candidate genes located in rat genomic regions for Nidd1-14/of or the syntenic regions in human genome.
American Psychological Association (APA)
Yamada, Takahisa& Kose, Hiroyuki& Ohta, Takeshi& Matsumoto, Kozo. 2012. Genetic Dissection of Complex Genetic Factor Involved in NIDDM of OLETF Rat. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482599
Modern Language Association (MLA)
Yamada, Takahisa…[et al.]. Genetic Dissection of Complex Genetic Factor Involved in NIDDM of OLETF Rat. Experimental Diabetes Research No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-482599
American Medical Association (AMA)
Yamada, Takahisa& Kose, Hiroyuki& Ohta, Takeshi& Matsumoto, Kozo. Genetic Dissection of Complex Genetic Factor Involved in NIDDM of OLETF Rat. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-482599
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482599