A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic SyndromesMyeloproliferative Neoplasms to Acute Myeloid Leukemia : A Case Series
Joint Authors
Luger, Selina M.
Mangan, James K.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
There has been a long history of reports describing a variety of paraneoplastic phenomena associated with myelodysplastic syndromes, particularly those with autoimmune manifestations.
We report here a series of patients with an antecedent myelodysplastic syndrome (MDS) or myeloproliferative neoplasm (MPN) that underwent aggressive transformation to acute myeloid leukemia (AML).
In each case, the transformation to AML was preceded by an inflammatory syndrome characterized by unilateral extremity swelling and an associated inflammatory skin infiltrate, as well as other signs of inflammation, including profound hyperferritinemia without evidence of a hemophagocytic syndrome.
We suggest that such an inflammatory syndrome may herald aggressive transformation of MDS/MPN to AML.
Patients with known MDS/MPN who present with these features may benefit from early bone marrow examination to assess disease status.
Early intervention with corticosteroids in select patients may result in improvement or resolution of the symptoms and permit intensive therapy for AML to be delivered.
American Psychological Association (APA)
Mangan, James K.& Luger, Selina M.. 2012. A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic SyndromesMyeloproliferative Neoplasms to Acute Myeloid Leukemia : A Case Series. Case Reports in Hematology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-482638
Modern Language Association (MLA)
Mangan, James K.& Luger, Selina M.. A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic SyndromesMyeloproliferative Neoplasms to Acute Myeloid Leukemia : A Case Series. Case Reports in Hematology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-482638
American Medical Association (AMA)
Mangan, James K.& Luger, Selina M.. A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic SyndromesMyeloproliferative Neoplasms to Acute Myeloid Leukemia : A Case Series. Case Reports in Hematology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-482638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482638