The Myocardial Unfolded Protein Response during Ischemic Cardiovascular Disease
Author
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Heart failure is a progressive and disabling disease.
The incidence of heart failure is also on the rise, particularly in the elderly of industrialized societies.
This is in part due to an increased ageing population, whom initially benefits from improved, and life-extending cardiovascular therapy, yet ultimately succumb to myocardial failure.
A major cause of heart failure is ischemia secondary to the sequence of events that is dyslipidemia, atherosclerosis, and myocardial infarction.
In the case of heart failure postmyocardial infarction, ischemia can lead to myocardial cell death by both necrosis and apoptosis.
The extent of myocyte death postinfarction is associated with adverse cardiac remodeling that can contribute to progressive heart chamber dilation, ventricular wall thinning, and the onset of loss of cardiac function.
In cardiomyocytes, recent studies indicate that myocardial ischemic injury activates the unfolded protein stress response (UPR) and this is associated with increased apoptosis.
This paper focuses on the intersection of ischemia, the UPR, and cell death in cardiomyocytes.
Targeting of the myocardial UPR may prove to be a viable target for the prevention of myocyte cell loss and the progression of heart failure due to ischemic injury.
American Psychological Association (APA)
Thorp, Edward B.. 2012. The Myocardial Unfolded Protein Response during Ischemic Cardiovascular Disease. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-482657
Modern Language Association (MLA)
Thorp, Edward B.. The Myocardial Unfolded Protein Response during Ischemic Cardiovascular Disease. Biochemistry Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-482657
American Medical Association (AMA)
Thorp, Edward B.. The Myocardial Unfolded Protein Response during Ischemic Cardiovascular Disease. Biochemistry Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-482657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482657