Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex
Joint Authors
Basavaraj, Basappa Veerbadraiah
Deveswaran, Rajamanickam
Bharath, Srinivasan
Sravya, Maddukuri
Madhavan, Varadharajan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-24
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The aim of this study was to investigate the use of inclusion complexation technique employing β-cyclodextrin in improving the dissolution profile of candesartan cilexetil, a BCS class-II drug, and to formulate the inclusion complex into orodispersible tablets.
The inclusion complexes were formed by physical mixing, kneading, coevaporation, and lyophilisation methods.
Inclusion complexes were characterized by FTIR, DSC, XRD, NMR, and mass spectral studies.
Inclusion complexes prepared using kneading, and lyophilisation techniques in the molar ratio 1 : 5 with β-cyclodextrin were used for formulating orodispersible tablets by direct compression with different superdisintegrants like croscarmellose sodium, crospovidone, sodium starch glycolate, and low substituted hydroxypropyl cellulose in varying concentrations.
The directly compressible powder was evaluated for precompression parameters, and the prepared orodispersible tablets were evaluated for postcompression parameters.
Drug-excipient compatibility studies showed no interaction, and characterization proved the formation of inclusion complex.
In vitro disintegration time was found to be within 3 minutes, and all the formulations showed complete drug release of 100% within 20 minutes.
The optimized formulation was found to be stable after 6 months and showed no significant change in drug content.
This work proved β-cyclodextrins to be effective solubilizing agent in improving the solubility of poorly water soluble drugs.
American Psychological Association (APA)
Sravya, Maddukuri& Deveswaran, Rajamanickam& Bharath, Srinivasan& Basavaraj, Basappa Veerbadraiah& Madhavan, Varadharajan. 2013. Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-482687
Modern Language Association (MLA)
Sravya, Maddukuri…[et al.]. Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex. Journal of Pharmaceutics No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-482687
American Medical Association (AMA)
Sravya, Maddukuri& Deveswaran, Rajamanickam& Bharath, Srinivasan& Basavaraj, Basappa Veerbadraiah& Madhavan, Varadharajan. Development of Orodispersible Tablets of Candesartan Cilexetil-β-cyclodextrin Complex. Journal of Pharmaceutics. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-482687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482687