Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase : Alcohol Use and Type 2 Diabetes in Japanese Men
Joint Authors
Kono, Suminori
Morita, Makiko
Yin, Guang
Tajima, Osamu
Tabata, Shinji
Ohnaka, Keizo
Source
Epidemiology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study investigated the association of ADH1B (rs1229984) and ALDH2 (rs671) polymorphisms with glucose tolerance status, as determined by a 75-g oral glucose tolerance test, and effect modification of these polymorphisms on the association between alcohol consumption and glucose intolerance in male officials of the Self-Defense Forces.
The study subjects included 1520 men with normal glucose tolerance, 553 with prediabetic condition (impaired fasting glucose and impaired glucose tolerance), and 235 men with type 2 diabetes.
There was an evident interaction between alcohol consumption and ADH1B polymorphism in relation to type 2 diabetes (interaction P=.03).
The ALDH24∗87Lys allele was associated with a decreased prevalence odds of type 2 diabetes regardless of alcohol consumption.
In conclusion, the ADH1B polymorphism modified the association between alcohol consumption and type 2 diabetes.
A positive association between alcohol consumption and type 2 diabetes was confounded by ALDH2 polymorphism.
American Psychological Association (APA)
Yin, Guang& Ohnaka, Keizo& Morita, Makiko& Tabata, Shinji& Tajima, Osamu& Kono, Suminori. 2010. Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase : Alcohol Use and Type 2 Diabetes in Japanese Men. Epidemiology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482695
Modern Language Association (MLA)
Yin, Guang…[et al.]. Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase : Alcohol Use and Type 2 Diabetes in Japanese Men. Epidemiology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482695
American Medical Association (AMA)
Yin, Guang& Ohnaka, Keizo& Morita, Makiko& Tabata, Shinji& Tajima, Osamu& Kono, Suminori. Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase : Alcohol Use and Type 2 Diabetes in Japanese Men. Epidemiology Research International. 2010. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482695