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Contemporary Clinical Management of Endometrial Cancer
Joint Authors
Dinkelspiel, Helen E.
Wright, Jason D.
Herzog, Thomas J.
Lewin, Sharyn N.
Source
Obstetrics and Gynecology International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although the contemporary management of endometrial cancer is straightforward in many ways, novel data has emerged over the past decade that has altered the clinical standards of care while generating new controversies that will require further investigation.
Fortunately most cases are diagnosed at early stages, but high-risk histologies and poorly differentiated tumors have high metastatic potential with a significantly worse prognosis.
Initial management typically requires surgery, but the role and extent of lymphadenectomy are debated especially with well-differentiated tumors.
With the changes in surgical staging, prognosis correlates more closely with stage, and the importance of cytology has been questioned and is under evaluation.
The roles of radiation in intermediate-risk patients and chemotherapy in high-risk patients are emerging.
The therapeutic index of brachytherapy needs to be considered, and the best sequencing of combined modalities needs to balance efficacy and toxicities.
Additionally novel targeted therapies show promise, and further studies are needed to determine the appropriate use of these new agents.
Management of endometrial cancer will continue to evolve as clinical trials continue to answer unsolved clinical questions.
American Psychological Association (APA)
Dinkelspiel, Helen E.& Wright, Jason D.& Lewin, Sharyn N.& Herzog, Thomas J.. 2013. Contemporary Clinical Management of Endometrial Cancer. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-482717
Modern Language Association (MLA)
Dinkelspiel, Helen E.…[et al.]. Contemporary Clinical Management of Endometrial Cancer. Obstetrics and Gynecology International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-482717
American Medical Association (AMA)
Dinkelspiel, Helen E.& Wright, Jason D.& Lewin, Sharyn N.& Herzog, Thomas J.. Contemporary Clinical Management of Endometrial Cancer. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-482717
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482717