![](/images/graphics-bg.png)
Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal
Joint Authors
Chakkera, Harini A.
Mazur, M. J.
Heilman, R. L.
Williams, J. W.
Hamawi, K.
Reddy, K. Sudhakar
Mulligan, David C.
Nijim, S.
Moss, Adyr A.
Devarapalli, Y.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Our aim was to study the impact of clinical acute rejection (CR) and subclinical rejection (SR) on outcomes in kidney transplant recipients treated with rapid steroid withdrawal (RSW).
Methods.
All patients who received a living or deceased donor kidney transplant and were treated with RSW were included.
The primary outcome was death-censored graft survival.
Biopsies with Banff borderline changes were included with the rejection groups.
Results.
457 kidney transplant recipients treated with RSW were included; 46 (10%) experienced SR, and 36 (7.8%) had CR.
Mean HLA mismatch was significantly higher in the CR group.
The Banff grade of rejection was higher in the CR group.
There was a larger proportion of patients in both rejection groups with the combination of IFTA and persistent inflammation on the follow-up protocol biopsy done at 1 year.
The estimated 5-year death-censored graft survival was 81% in SR, 78% in CR, and 97% in the control group (P<.0001).
Significant differences were observed in allograft survival between the CR and control group (HR 9.06, 95% CI 3.39–24.2) and between the SR and control group (HR 4.22, 95% CI 1.30–13.7).
Conclusion.
Both SR and CR are associated with an inferior graft survival in recipients on RSW.
American Psychological Association (APA)
Heilman, R. L.& Nijim, S.& Chakkera, Harini A.& Devarapalli, Y.& Moss, Adyr A.& Mulligan, David C.…[et al.]. 2011. Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482729
Modern Language Association (MLA)
Heilman, R. L.…[et al.]. Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal. Journal of Transplantation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-482729
American Medical Association (AMA)
Heilman, R. L.& Nijim, S.& Chakkera, Harini A.& Devarapalli, Y.& Moss, Adyr A.& Mulligan, David C.…[et al.]. Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-482729
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482729