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Malignant Melanoma and Its Stromal Nonimmune Microecosystem
Joint Authors
Delvenne, Philippe
Piérard, Gérald E.
Piérard-Franchimont, Claudine
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In recent years, rapid advances were reached in the understanding of a series of biologic signals influencing cutaneous malignant melanoma (CMM) cells.
CMM is in close contact with a peculiar dermal extracellular matrix (ECM).
Stromal cells store and release various structural ECM components.
The impact on CMM growth and progression is mediated through strong and long-lasting effects of ECM products.
This paper summarizes some peculiar aspects of the peri-CMM stroma showing intracytoplasmic loads in Factor XIIIa, CD34, versican, and α (IV) collagen chains.
The restricted peri-CMM skin territory exhibiting such changes corresponds to the area showing neoangiogenesis and extravascular unicellular metastatic spread.
The latter inconspicuous migratory CMM cells possibly correspond to CMM stem cells or to CMM cells with aberrant HOX gene expression.
Their presence is associated with an increased risk for metastases in the regional sentinel lymph nodes.
In conclusion, the CMM-stroma connection appears crucial to the growth regulation, invasiveness and initial metastatic spread of CMM cells.
Although much remains to be learned in this field, the active intervention of the peri-CMM stroma is likely involved in the inconspicuous early metastatic migration of CMM cells.
American Psychological Association (APA)
Piérard, Gérald E.& Piérard-Franchimont, Claudine& Delvenne, Philippe. 2012. Malignant Melanoma and Its Stromal Nonimmune Microecosystem. Journal of Oncology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-482745
Modern Language Association (MLA)
Piérard, Gérald E.…[et al.]. Malignant Melanoma and Its Stromal Nonimmune Microecosystem. Journal of Oncology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-482745
American Medical Association (AMA)
Piérard, Gérald E.& Piérard-Franchimont, Claudine& Delvenne, Philippe. Malignant Melanoma and Its Stromal Nonimmune Microecosystem. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-482745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482745