![](/images/graphics-bg.png)
Mouse Models for Blistering Skin Disorders
Joint Authors
Koch, Peter J.
Chen, Jiangli
Ganeshan, Radhika
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases.
In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mutations and disease phenotypes.
This review focuses on mice that lack the desmosomal cadherins desmoglein 3 or desmocollin 3 in stratified epithelia.
A comparison of the phenotypes observed in these mouse lines is provided and the relationship between the mutant mouse phenotypes and human diseases, in particular pemphigus vulgaris, is discussed.
Furthermore, we will discuss the advantages and potential limitations of genetically engineered mouse lines in our ongoing quest to understand blistering skin diseases.
American Psychological Association (APA)
Ganeshan, Radhika& Chen, Jiangli& Koch, Peter J.. 2010. Mouse Models for Blistering Skin Disorders. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-482759
Modern Language Association (MLA)
Ganeshan, Radhika…[et al.]. Mouse Models for Blistering Skin Disorders. Dermatology Research and Practice No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-482759
American Medical Association (AMA)
Ganeshan, Radhika& Chen, Jiangli& Koch, Peter J.. Mouse Models for Blistering Skin Disorders. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-482759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482759