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Consumption of Galactooligosaccharides together with Probiotics Stimulates the In Vitro Peripheral Blood Mononuclear Cell Proliferation and IFNγ Production in Healthy Men
Joint Authors
Holma, Reetta
Poussa, Tuija
Korpela, Riitta
Adlercreutz, Herman
Kekkonen, Riina A.
Hatakka, Katja
Vaarala, Outi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Probiotics and prebiotics modify the intestinal environment and could have immunomodulatory effects.
The proliferation of spontaneous and phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMCs) and their production of interleukin-4, interleukin-5, transforming growth factor-β1, and interferon-γ (IFNγ) were determined in eighteen men at the baseline and during a 2-week period of probiotics (mixture of Lactobacillus rhamnosus GG, Lactobacillus rhamnosus LC705, Propionibacterium freudenreichii ssp.
shermanii JS, and Bifidobacterium breve Bb99) and galactooligosaccharides (GOSs) (3.8 g/day).
The spontaneous and stimulated proliferation of PBMC increased from the baseline during probiotics+GOS (P<0.001).
The secretion of IFNγ, but not other cytokines, by stimulated PBMC increased during the same period (P<0.05).
In conclusion, the consumption of this probiotic mixture including GOS appears to increase the capacity of PBMC to proliferate and release IFNγ selectively in healthy men.
American Psychological Association (APA)
Holma, Reetta& Kekkonen, Riina A.& Hatakka, Katja& Poussa, Tuija& Vaarala, Outi& Adlercreutz, Herman…[et al.]. 2011. Consumption of Galactooligosaccharides together with Probiotics Stimulates the In Vitro Peripheral Blood Mononuclear Cell Proliferation and IFNγ Production in Healthy Men. ISRN Immunology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482787
Modern Language Association (MLA)
Holma, Reetta…[et al.]. Consumption of Galactooligosaccharides together with Probiotics Stimulates the In Vitro Peripheral Blood Mononuclear Cell Proliferation and IFNγ Production in Healthy Men. ISRN Immunology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-482787
American Medical Association (AMA)
Holma, Reetta& Kekkonen, Riina A.& Hatakka, Katja& Poussa, Tuija& Vaarala, Outi& Adlercreutz, Herman…[et al.]. Consumption of Galactooligosaccharides together with Probiotics Stimulates the In Vitro Peripheral Blood Mononuclear Cell Proliferation and IFNγ Production in Healthy Men. ISRN Immunology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482787
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482787