Macrophage Autophagy in Atherosclerosis
Joint Authors
Platt, Andrew M.
Ialenti, Armando
Grassia, Gianluca
Maffia, Pasquale
Maiuri, Maria Chiara
Carnuccio, Rosa
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Macrophages play crucial roles in atherosclerotic immune responses.
Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
AP is a cellular catabolic process involving the delivery of cytoplasmic contents to the lysosomal machinery for ultimate degradation and recycling.
Basal levels of macrophage AP play an essential role in atheroprotection during early atherosclerosis.
However, AP becomes dysfunctional in the more advanced stages of the pathology and its deficiency promotes vascular inflammation, oxidative stress, and plaque necrosis.
In this paper, we will discuss the role of macrophages and AP in atherosclerosis and the emerging evidence demonstrating the contribution of macrophage AP to vascular pathology.
Finally, we will discuss how AP could be targeted for therapeutic utility.
American Psychological Association (APA)
Maiuri, Maria Chiara& Grassia, Gianluca& Platt, Andrew M.& Carnuccio, Rosa& Ialenti, Armando& Maffia, Pasquale. 2013. Macrophage Autophagy in Atherosclerosis. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-482792
Modern Language Association (MLA)
Maiuri, Maria Chiara…[et al.]. Macrophage Autophagy in Atherosclerosis. Mediators of Inflammation No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-482792
American Medical Association (AMA)
Maiuri, Maria Chiara& Grassia, Gianluca& Platt, Andrew M.& Carnuccio, Rosa& Ialenti, Armando& Maffia, Pasquale. Macrophage Autophagy in Atherosclerosis. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-482792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482792