Characterization of Selective Antibacterial Peptides by Polarity Index
Joint Authors
Buhse, Thomas
Samaniego, J. L.
Negron-Mendoza, A.
Ramos-Bernal, S.
Mosqueira, F. G.
Polanco, Carlos
Castanon-Gonzalez, J. A.
Source
International Journal of Peptides
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the recent decades, antibacterial peptides have occupied a strategic position for pharmaceutical drug applications and became subject of intense research activities since they are used to strengthen the immune system of all living organisms by protecting them from pathogenic bacteria.
This work proposes a simple and easy statistical/computational method through a peptide polarity index measure by which an antibacterial peptide subgroup can be efficiently identified, that is, characterized by a high toxicity to bacterial membranes but presents a low toxicity to mammal cells.
These peptides also have the feature not to adopt to an alpha-helicoidal structure in aqueous solution.
The double-blind test carried out to the whole Antimicrobial Peptide Database (November 2011) showed an accuracy of 90% applying the polarity index method for the identification of such antibacterial peptide groups.Erratum to “Characterization of Selective Antibacterial Peptides by Polarity Index”dx.doi.org/10.1155/2012/613053
American Psychological Association (APA)
Polanco, Carlos& Samaniego, J. L.& Buhse, Thomas& Mosqueira, F. G.& Negron-Mendoza, A.& Ramos-Bernal, S.…[et al.]. 2012. Characterization of Selective Antibacterial Peptides by Polarity Index. International Journal of Peptides،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-482827
Modern Language Association (MLA)
Polanco, Carlos…[et al.]. Characterization of Selective Antibacterial Peptides by Polarity Index. International Journal of Peptides No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-482827
American Medical Association (AMA)
Polanco, Carlos& Samaniego, J. L.& Buhse, Thomas& Mosqueira, F. G.& Negron-Mendoza, A.& Ramos-Bernal, S.…[et al.]. Characterization of Selective Antibacterial Peptides by Polarity Index. International Journal of Peptides. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-482827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482827