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Neurobiology Underlying Fibromyalgia Symptoms
Joint Authors
Bushnell, M. Catherine
Ceko, Marta
Gracely, Richard H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Fibromyalgia is characterized by chronic widespread pain, clinical symptoms that include cognitive and sleep disturbances, and other abnormalities such as increased sensitivity to painful stimuli, increased sensitivity to multiple sensory modalities, and altered pain modulatory mechanisms.
Here we relate experimental findings of fibromyalgia symptoms to anatomical and functional brain changes.
Neuroimaging studies show augmented sensory processing in pain-related areas, which, together with gray matter decreases and neurochemical abnormalities in areas related to pain modulation, supports the psychophysical evidence of altered pain perception and inhibition.
Gray matter decreases in areas related to emotional decision making and working memory suggest that cognitive disturbances could be related to brain alterations.
Altered levels of neurotransmitters involved in sleep regulation link disordered sleep to neurochemical abnormalities.
Thus, current evidence supports the view that at least some fibromyalgia symptoms are associated with brain dysfunctions or alterations, giving the long-held “it is all in your head” view of the disorder a new meaning.
American Psychological Association (APA)
Ceko, Marta& Bushnell, M. Catherine& Gracely, Richard H.. 2011. Neurobiology Underlying Fibromyalgia Symptoms. Pain Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-482853
Modern Language Association (MLA)
Ceko, Marta…[et al.]. Neurobiology Underlying Fibromyalgia Symptoms. Pain Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-482853
American Medical Association (AMA)
Ceko, Marta& Bushnell, M. Catherine& Gracely, Richard H.. Neurobiology Underlying Fibromyalgia Symptoms. Pain Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-482853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482853