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Randomised Double-Blind Trial of Combination Antibiotic Therapy in Rheumatoid Arthritis
Joint Authors
Vallance, Alena
Mackworth-Young, Charles
Smith, Angela
Charles, Peter
Potier, Tara
Doré, Caroline
Source
International Journal of Rheumatology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
A combination of intravenous clindamycin and oral tetracycline has been used for many years as a treatment for active rheumatoid arthritis (RA), despite the absence of good evidence for its efficacy.
A single-blind pilot study of this therapy suggested that a double-blind placebo-controlled trial was warranted.
Methods.
Patients with active RA were randomised in a 2 : 1 ratio to receive active treatment or placebo for 25 weeks.
The active treatment consisted of intravenous clindamycin in a reducing regime, and oral tetracycline twice daily three times a week.
50 patients were to be recruited.
The primary outcome measure was the proportion of patients achieving an ACR20 response.
Results.
An interim statistical analysis was performed after 20 patients had completed the study.
Two patients in the active group achieved an ACR20 response, with none in the placebo group (NS).
There was a better ESR20 response in the placebo group (P=.02).
There were no other significant differences between the groups.
The results indicated that it was unlikely that a significant difference in ACR20 response would emerge if the remaining 30 patients were recruited.
The trial was therefore halted.
Conclusion.
This antibiotic regime is unlikely to be a valuable therapy for active rheumatoid arthritis.
American Psychological Association (APA)
Smith, Angela& Doré, Caroline& Charles, Peter& Vallance, Alena& Potier, Tara& Mackworth-Young, Charles. 2011. Randomised Double-Blind Trial of Combination Antibiotic Therapy in Rheumatoid Arthritis. International Journal of Rheumatology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482861
Modern Language Association (MLA)
Smith, Angela…[et al.]. Randomised Double-Blind Trial of Combination Antibiotic Therapy in Rheumatoid Arthritis. International Journal of Rheumatology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-482861
American Medical Association (AMA)
Smith, Angela& Doré, Caroline& Charles, Peter& Vallance, Alena& Potier, Tara& Mackworth-Young, Charles. Randomised Double-Blind Trial of Combination Antibiotic Therapy in Rheumatoid Arthritis. International Journal of Rheumatology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482861