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The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans
Joint Authors
Salciccioli, Louis
Patel, Rinkesh
Kamran, Haroon
Lazar, Jason M.
Maraj, IIir
Berman, Heather
Source
International Journal of Hypertension
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Aging is associated with increased central aortic systolic pressure (CSP) and pulse pressure which are predictive of cardiovascular events.
Mechanisms implicated for higher central pressures include a higher forward incident pressure wave (P1), higher augmented pressure (AP), and shorter reflected wave round trip travel time (Tr).
African-Americans (AA) have more frequent and deleterious blood pressure elevation.
Using applanation tonometry, we studied the association of age and CSP with P1 and AP in 900 AA subjects.
Data showed that in subjects ≤50 years old, CSP was mediated by AP but not P1 or Tr, whereas in those >50, CSP was mediated by both AP and P1 and to a lesser extent by Tr.
Predictive models were significant (R2=0.97) for both age groups.
In conclusion, wave reflection is the primary determinant of CSP in younger AA, while in older subjects, CSP is mediated by both the magnitude and timing of wave reflection as well as aortic impedance.
American Psychological Association (APA)
Kamran, Haroon& Lazar, Jason M.& Patel, Rinkesh& Maraj, IIir& Berman, Heather& Salciccioli, Louis. 2011. The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans. International Journal of Hypertension،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482871
Modern Language Association (MLA)
Kamran, Haroon…[et al.]. The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans. International Journal of Hypertension No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-482871
American Medical Association (AMA)
Kamran, Haroon& Lazar, Jason M.& Patel, Rinkesh& Maraj, IIir& Berman, Heather& Salciccioli, Louis. The Age-Dependent Contribution of Aortic Incident and Reflected Pressure Waves to Central Blood Pressure in African-Americans. International Journal of Hypertension. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-482871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482871