The Role of Uncoupling Proteins in Diabetes Mellitus
Joint Authors
Li, Ji
Li, Wen-Jian
Liu, Jing
Wang, Chun-Ming
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Uncoupling proteins (UCPs) are anion carriers expressed in the mitochondrial inner membrane that uncouple oxygen consumption by the respiratory chain from ATP synthesis.
The physiological functions of UCPs have long been debated since the new UCPs (UCP2 to 5) were discovered, and the role of UCPs in the pathogeneses of diabetes mellitus is one of the hottest topics.
UCPs are thought to be activated by superoxide and then decrease mitochondrial free radicals generation; this may provide a protective effect on diabetes mellitus that is under the oxidative stress conditions.
UCP1 is considered to be a candidate gene for diabetes because of its role in thermogenesis and energy expenditure.
UCP2 is expressed in several tissues and acts in the negative regulation of insulin secretion by β-cells and in fatty acid metabolism.
UCP3 plays a role in fatty acid metabolism and energy homeostasis and modulates insulin sensitivity.
Several gene polymorphisms of UCP1, UCP2, and UCP3 were reported to be associated with diabetes.
The progress in the role of UCP1, UCP2, and UCP3 on diabetes mellitus is summarized in this review.
American Psychological Association (APA)
Liu, Jing& Li, Ji& Li, Wen-Jian& Wang, Chun-Ming. 2013. The Role of Uncoupling Proteins in Diabetes Mellitus. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482889
Modern Language Association (MLA)
Liu, Jing…[et al.]. The Role of Uncoupling Proteins in Diabetes Mellitus. Journal of Diabetes Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-482889
American Medical Association (AMA)
Liu, Jing& Li, Ji& Li, Wen-Jian& Wang, Chun-Ming. The Role of Uncoupling Proteins in Diabetes Mellitus. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-482889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482889