Zinc Deficiency and Zinc Therapy Efficacy with Reduction of Serum Free Copper in Alzheimer’s Disease
Joint Authors
Kaur, Sukhvir
Brewer, George J.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
We are in the midst of an epidemic of Alzheimer’s disease (AD) in developed countries.
We have postulated that ingestion of inorganic copper from drinking water and taking supplement pills and a high fat diet are major causative factors.
Ingestion of inorganic copper can directly raise the blood free copper level.
Blood free copper has been shown by the Squitti group to be elevated in AD, to correlate with cognition, and to predict cognition loss.
Secondly, we have shown that AD patients are zinc deficient compared to age matched controls.
Zinc is important in neuronal protection.
We carried out a 6-month small double blind trial of a new zinc formulation on AD patients.
We found that in patients 70 years and older, zinc therapy protected against cognition decline compared to placebo controls.
We also found that zinc therapy significantly lowered blood free copper levels.
So zinc efficacy could be due to restoring neuronal zinc levels, to lowering blood free copper levels, or to both.
American Psychological Association (APA)
Brewer, George J.& Kaur, Sukhvir. 2013. Zinc Deficiency and Zinc Therapy Efficacy with Reduction of Serum Free Copper in Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-482936
Modern Language Association (MLA)
Brewer, George J.& Kaur, Sukhvir. Zinc Deficiency and Zinc Therapy Efficacy with Reduction of Serum Free Copper in Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-4.
https://search.emarefa.net/detail/BIM-482936
American Medical Association (AMA)
Brewer, George J.& Kaur, Sukhvir. Zinc Deficiency and Zinc Therapy Efficacy with Reduction of Serum Free Copper in Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-4.
https://search.emarefa.net/detail/BIM-482936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482936