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Branched RNA : A New Architecture for RNA Interference
Joint Authors
Perales, José Carlos
Aviñó, Anna
Ocampo, Sandra M.
Eritja, Ramon
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-06
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Branched RNAs with two and four strands were synthesized.
These structures were used to obtain branched siRNA.
The branched siRNA duplexes had similar inhibitory capacity as those of unmodified siRNA duplexes, as deduced from gene silencing experiments of the TNF-α protein.
Branched RNAs are considered novel structures for siRNA technology, and they provide an innovative tool for specific gene inhibition.
As the method described here is compatible with most RNA modifications described to date, these compounds may be further functionalized to obtain more potent siRNA derivatives and can be attached to suitable delivery systems.
American Psychological Association (APA)
Aviñó, Anna& Ocampo, Sandra M.& Perales, José Carlos& Eritja, Ramon. 2011. Branched RNA : A New Architecture for RNA Interference. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-482986
Modern Language Association (MLA)
Aviñó, Anna…[et al.]. Branched RNA : A New Architecture for RNA Interference. Journal of Nucleic Acids No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-482986
American Medical Association (AMA)
Aviñó, Anna& Ocampo, Sandra M.& Perales, José Carlos& Eritja, Ramon. Branched RNA : A New Architecture for RNA Interference. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-482986
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-482986