IL-17F Induces CCL20 in Bronchial Epithelial Cells
Joint Authors
Nozato, Kyoko
Ishii, Yukio
Kokubu, Fumio
Satoh, Hiroaki
Kawaguchi, Mio
Hizawa, Nobuyuki
Fujita, Junichi
Huang, Shau-Ku
Ohara, Gen
Morishima, Yuko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
IL-17F plays a crucial role in airway inflammatory diseases including asthma, but its function has not been fully elucidated.
CCL20 is also involved in allergic airway inflammation, while its regulatory mechanisms remain to be defined.
To further identify a novel role of IL-17F, the expression of CCL20 by IL-17F in bronchial epithelial cells and the signaling mechanisms involved were investigated.
Bronchial epithelial cells were stimulated with IL-17F, and the levels of CCL20 gene and protein measured, with the effects of the addition of various kinase inhibitors and siRNAs also investigated.
IL-17F significantly induced the expression of CCL20 gene and protein.
Pretreatment with inhibitors for MEK1/2, Raf1 and MSK1, and overexpression of a Raf1 dominant-negative mutant significantly diminished IL-17F-induced CCL20 production.
Moreover, transfection of the siRNAs targeting MSK1, p90RSK, and CREB blocked CCL20 expression.
These findings suggest that IL-17F is able to induce CCL20 via Raf1-MEK1/2-ERK1/2-MSK1/p90RSK-CREB signaling pathway in bronchial epithelial cells.
The IL-17F/CCL20 axis may be a novel pharmacological target for asthma.
American Psychological Association (APA)
Nozato, Kyoko& Fujita, Junichi& Kawaguchi, Mio& Ohara, Gen& Morishima, Yuko& Ishii, Yukio…[et al.]. 2011. IL-17F Induces CCL20 in Bronchial Epithelial Cells. Journal of Allergy،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-483009
Modern Language Association (MLA)
Nozato, Kyoko…[et al.]. IL-17F Induces CCL20 in Bronchial Epithelial Cells. Journal of Allergy No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-483009
American Medical Association (AMA)
Nozato, Kyoko& Fujita, Junichi& Kawaguchi, Mio& Ohara, Gen& Morishima, Yuko& Ishii, Yukio…[et al.]. IL-17F Induces CCL20 in Bronchial Epithelial Cells. Journal of Allergy. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-483009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483009