Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation
Joint Authors
Wang, Yiner
Neumann, Harald
Linnartz, Bettina
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Elimination of extracellular aggregates and apoptotic neural membranes without inflammation is crucial for brain tissue homeostasis.
In the mammalian central nervous system, essential molecules in this process are the Fc receptors and the DAP12-associated receptors which both trigger the microglial immunoreceptor tyrosine-based activation motif- (ITAM-) Syk-signaling cascade.
Microglial triggering receptor expressed on myeloid cells-2 (TREM2), signal regulatory protein-β1, and complement receptor-3 (CD11b/CD18) signal via the adaptor protein DAP12 and activate phagocytic activity of microglia.
Microglial ITAM-signaling receptors are counter-regulated by immunoreceptor tyrosine-based inhibition motif- (ITIM-) signaling molecules such as sialic acid-binding immunoglobulin superfamily lectins (Siglecs).
Siglecs can suppress the proinflammatory and phagocytic activity of microglia via ITIM signaling.
Moreover, microglial neurotoxicity is alleviated via interaction of Siglec-11 with sialic acids on the neuronal glycocalyx.
Thus, ITAM- and ITIM-signaling receptors modulate microglial phagocytosis and cytokine expression during neuroinflammatory processes.
Their dysfunction could lead to impaired phagocytic clearance and neurodegeneration triggered by chronic inflammation.
American Psychological Association (APA)
Linnartz, Bettina& Wang, Yiner& Neumann, Harald. 2010. Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-483047
Modern Language Association (MLA)
Linnartz, Bettina…[et al.]. Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-483047
American Medical Association (AMA)
Linnartz, Bettina& Wang, Yiner& Neumann, Harald. Microglial Immunoreceptor Tyrosine-Based Activation and Inhibition Motif Signaling in Neuroinflammation. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-483047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483047