Lipid Peroxidation and Paraoxonase-1 Activity in Celiac Disease
Joint Authors
Saturni, Letizia
Di Sario, Antonio
Bacchetti, Tiziana
Candelaresi, Cinzia
Benedetti, Antonio
Manzella, Nicola
Ferretti, Gianna
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Paraoxonase-1 (PON1) plays an antioxidant and anti-inflammatory role.
Aim of the study was to investigate the alteration of paraoxonase-1 activity in celiac disease (CD), an intestinal disorder characterized by toxic injury exerted by gluten peptides.
Activities of PON1, levels of biochemical markers of lipid peroxidation and total antioxidant capacity were evaluated in serum obtained from 27 celiac patients (11 at diagnosis, 16 treated with gluten free diet) and 25 healthy subjects.
Moreover, the serum susceptibility of Cu2+-induced lipid peroxidation was investigated in controls and patients.
The results showed a lower PON1 activity in serum of both groups of celiac patients with respect to control subjects.
PON1 activity in CD was related with markers of disease severity and was negatively correlated with the levels of lipid hydroperoxide and with the susceptibility of serum to lipid peroxidation induced in vitro by metal ions.
The alteration of PON1 activity and markers of lipid peroxidation realized at lower extent in patients who were on a gluten-free diet.
American Psychological Association (APA)
Ferretti, Gianna& Bacchetti, Tiziana& Saturni, Letizia& Manzella, Nicola& Candelaresi, Cinzia& Benedetti, Antonio…[et al.]. 2012. Lipid Peroxidation and Paraoxonase-1 Activity in Celiac Disease. Journal of Lipids،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-483049
Modern Language Association (MLA)
Ferretti, Gianna…[et al.]. Lipid Peroxidation and Paraoxonase-1 Activity in Celiac Disease. Journal of Lipids No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-483049
American Medical Association (AMA)
Ferretti, Gianna& Bacchetti, Tiziana& Saturni, Letizia& Manzella, Nicola& Candelaresi, Cinzia& Benedetti, Antonio…[et al.]. Lipid Peroxidation and Paraoxonase-1 Activity in Celiac Disease. Journal of Lipids. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-483049
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483049