Development and In Vitro Characterization of Hyaluronic Acid-Based Coatings for Implant-Associated Local Drug Delivery Systems
Joint Authors
Teske, Michael
Minrath, Ingo
Petersen, Svea
Sternberg, Katrin
Schmitz, Klaus-Peter
Kaule, Sebastian
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The development of drug-eluting coatings based on hyaluronic acid (HA) is especially promising for implant-associated local drug delivery (LDD) systems, whose implantation provokes high insertion forces, as, for instance, cochlear implants or drug-coated balloons (DCB).
The lubricious character of HA can then reduce the coefficient of friction and serve as drug reservoir simultaneously.
In this context, we investigated several plasma- and wet-chemical methods for the deposition of HA-based coatings with LDD function on polyamide 12 as a model implant surface, conventionally used for DCB.
In contrast to aminosilane, epoxy silane surface layers allowed the covalent attachment of a smooth and uniform HA base layer, which provided good adherence of further HA layers deposited by manual dip coating at a subsequent processing stage.
The applied HA-crosslinking procedure during dip coating influences the transfer and release of paclitaxel, which could be reproducibly incorporated via infiltration.
While crosslinking with N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride provided HA coatings on DCB, which allowed for an efficient paclitaxel transfer upon expansion in a vessel model, crosslinking with glutardialdehyde resulted in a slower drug release being more appropriate for implants with longer residence time in the body.
The developed HA coating is hence well suited for spontaneous and sustained LDD.
American Psychological Association (APA)
Petersen, Svea& Kaule, Sebastian& Teske, Michael& Minrath, Ingo& Schmitz, Klaus-Peter& Sternberg, Katrin. 2013. Development and In Vitro Characterization of Hyaluronic Acid-Based Coatings for Implant-Associated Local Drug Delivery Systems. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-483083
Modern Language Association (MLA)
Petersen, Svea…[et al.]. Development and In Vitro Characterization of Hyaluronic Acid-Based Coatings for Implant-Associated Local Drug Delivery Systems. Journal of Chemistry No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-483083
American Medical Association (AMA)
Petersen, Svea& Kaule, Sebastian& Teske, Michael& Minrath, Ingo& Schmitz, Klaus-Peter& Sternberg, Katrin. Development and In Vitro Characterization of Hyaluronic Acid-Based Coatings for Implant-Associated Local Drug Delivery Systems. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-483083
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483083