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Fine-Needle Aspiration Biopsy of Hepatocellular Carcinoma and Related Hepatocellular Nodular Lesions in Cirrhosis : Controversies, Challenges, and Expectations
Author
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
The role of hepatic fine-needle aspiration (FNA) biopsy has evolved.
Advances in imaging modalities have obviated the need for tissue confirmation in most hepatocellular carcinomas (HCCs).
There is risk of needle-tract seeding.
Increasingly, small nodules are being detected on ultrasound surveillance of high-risk patients.
Diagnostic challenges associated with cirrhosis include distinction of benign hepatocellular nodules, namely, large regenerative nodules and dysplastic nodules, from reactive hepatocytes; and distinction of well-differentiated HCCs from benign hepatocellular nodules.
This paper will discuss (i) controversies regarding preoperative/pretransplantation FNA diagnosis of HCC, (ii) update of biological evolution, nomenclature, and histopathologic criteria for diagnosis of precancerous nodules and small HCCs, and (iii) algorithmic approach to FNA diagnosis of hepatocellular nodules.
Optimal results depend on dedicated radiologist-cytopathologist team, on-site cytology service; combined cytohistologic approach, immunohistochemistry, and clinicopathologic correlation.
Hepatic FNA is likely to be incorporated as a point of care as we move towards personalized medicine.
American Psychological Association (APA)
Wee, Aileen. 2011. Fine-Needle Aspiration Biopsy of Hepatocellular Carcinoma and Related Hepatocellular Nodular Lesions in Cirrhosis : Controversies, Challenges, and Expectations. Pathology Research International،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-483089
Modern Language Association (MLA)
Wee, Aileen. Fine-Needle Aspiration Biopsy of Hepatocellular Carcinoma and Related Hepatocellular Nodular Lesions in Cirrhosis : Controversies, Challenges, and Expectations. Pathology Research International No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-483089
American Medical Association (AMA)
Wee, Aileen. Fine-Needle Aspiration Biopsy of Hepatocellular Carcinoma and Related Hepatocellular Nodular Lesions in Cirrhosis : Controversies, Challenges, and Expectations. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-483089
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483089