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Evidence for Bone Marrow Adult Stem Cell Plasticity : Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation
Joint Authors
Catacchio, Ivana
Racanelli, Vito
Vacca, Angelo
Ria, Roberto
Reale, Antonia
De Luisi, Annunziata
Berardi, Simona
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-27
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
In contrast to the pluripotent embryonic stem cells (ESCs) which are able to give rise to all cell types of the body, mammalian adult stem cells (ASCs) appeared to be more limited in their differentiation potential and to be committed to their tissue of origin.
Recently, surprising new findings have contradicted central dogmas of commitment of ASCs by showing their plasticity to differentiate across tissue lineage boundaries, irrespective of classical germ layer designations.
The present paper supports the plasticity of the bone marrow stem cells (BMSCs), bringing the most striking and the latest evidences of the transdifferentiation properties of the bone marrow hematopoietic and mesenchymal stem cells (BMHSCs, and BMMSCs), the two BM populations of ASCs better characterized.
In addition, we report the possible mechanisms that may explain these events, outlining the clinical importance of these phenomena and the relative problems.
American Psychological Association (APA)
Catacchio, Ivana& Berardi, Simona& Reale, Antonia& De Luisi, Annunziata& Racanelli, Vito& Vacca, Angelo…[et al.]. 2013. Evidence for Bone Marrow Adult Stem Cell Plasticity : Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation. Stem Cells International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-483107
Modern Language Association (MLA)
Catacchio, Ivana…[et al.]. Evidence for Bone Marrow Adult Stem Cell Plasticity : Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation. Stem Cells International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-483107
American Medical Association (AMA)
Catacchio, Ivana& Berardi, Simona& Reale, Antonia& De Luisi, Annunziata& Racanelli, Vito& Vacca, Angelo…[et al.]. Evidence for Bone Marrow Adult Stem Cell Plasticity : Properties, Molecular Mechanisms, Negative Aspects, and Clinical Applications of Hematopoietic and Mesenchymal Stem Cells Transdifferentiation. Stem Cells International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-483107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483107