Abnormalities of the Ventilatory Equivalent for Carbon Dioxide in Patients with Chronic Heart Failure
Joint Authors
Carroll, Sean
Ingle, Lee
Clark, Andrew L.
Goode, Kevin
Cleland, John G.
Sloan, Rebecca
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
The relation between minute ventilation (VE) and carbon dioxide production (VCO2) can be characterised by the instantaneous ratio of ventilation to carbon dioxide production, the ventilatory equivalent for CO2 (VEqCO2).
We hypothesised that the time taken to achieve the lowest VEqCO2 (time to VEqCO2 nadir) may be a prognostic marker in patients with chronic heart failure (CHF).
Methods.
Patients and healthy controls underwent a symptom-limited, cardiopulmonary exercise test (CPET) on a treadmill to volitional exhaustion.
Results.
423 patients with CHF (mean age 63±12 years; 80% males) and 78 healthy controls (62% males; age 61±11 years) were recruited.
Time to VEqCO2 nadir was shorter in patients than controls (327±204 s versus 514±187 s; P=0.0001).
Univariable predictors of all-cause mortality included peak oxygen uptake (X2=53.0), VEqCO2 nadir (X2=47.9), and time to VEqCO2 nadir (X2=24.0).
In an adjusted Cox multivariable proportional hazards model, peak oxygen uptake (X2=16.7) and VEqCO2 nadir (X2=17.9) were the most significant independent predictors of all-cause mortality.
Conclusion.
The time to VEqCO2 nadir was shorter in patients with CHF than in normal subjects and was a predictor of subsequent mortality.
American Psychological Association (APA)
Ingle, Lee& Sloan, Rebecca& Carroll, Sean& Goode, Kevin& Cleland, John G.& Clark, Andrew L.. 2012. Abnormalities of the Ventilatory Equivalent for Carbon Dioxide in Patients with Chronic Heart Failure. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-483112
Modern Language Association (MLA)
Ingle, Lee…[et al.]. Abnormalities of the Ventilatory Equivalent for Carbon Dioxide in Patients with Chronic Heart Failure. Pulmonary Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-483112
American Medical Association (AMA)
Ingle, Lee& Sloan, Rebecca& Carroll, Sean& Goode, Kevin& Cleland, John G.& Clark, Andrew L.. Abnormalities of the Ventilatory Equivalent for Carbon Dioxide in Patients with Chronic Heart Failure. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-483112
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483112