Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males : A Randomized Controlled Study
Joint Authors
Kanai, Yoshiaki
Katagiri, Mikiyuki
Ikuta, Tomoki
Shirasawa, Takuji
Mori, Akemi
Watanabe, Tami
Fukushima, Shinobu
Tatefuji, Tomoki
Konno, Hiroyuki
Tani, Hiroko
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Melinjo (Gnetum gnemon L.) seed extract (MSE) containing trans-resveratrol (3,5,4′-trihydroxy-trans-stilbene) and other derivatives exerts various beneficial effects.
However, its mechanism of action in humans remains unknown.
In this study, we aimed to investigate beneficial effects of MSE in healthy adult males.
In this double-blind, randomized controlled study, 30 males aged 35–70 years with ≤10% flow-mediated dilatation received placebo or 750 mg MSE powder for 8 weeks, and twenty-nine males (45.1±8.8 years old) completed the trial.
There was a significant difference in the melinjo and placebo groups.
Compared with the placebo control, MSE significantly reduced serum uric acid at 4 weeks and 8 weeks (n=14 and 15, resp.).
HDL cholesterol was significantly increased in the melinjo group.
To clarify the mechanism of MSE for reducing uric acid, we investigated xanthine oxidase inhibitory activity, angiotensin II type 1 (AT1) receptor binding inhibition rate, and agonistic activities for PPARα and PPARγ.
MSE, trans-resveratrol, and a resveratrol dimer, gnetin C (GC), significantly inhibit AT1 receptor binding and exhibit mild agonistic activities for PPARα and PPARγ.
In conclusion, MSE may decrease serum uric acid regardless of insulin resistance and may improve lipid metabolism by increasing HDL cholesterol.
American Psychological Association (APA)
Konno, Hiroyuki& Kanai, Yoshiaki& Katagiri, Mikiyuki& Watanabe, Tami& Mori, Akemi& Ikuta, Tomoki…[et al.]. 2013. Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males : A Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483114
Modern Language Association (MLA)
Konno, Hiroyuki…[et al.]. Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males : A Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-483114
American Medical Association (AMA)
Konno, Hiroyuki& Kanai, Yoshiaki& Katagiri, Mikiyuki& Watanabe, Tami& Mori, Akemi& Ikuta, Tomoki…[et al.]. Melinjo (Gnetum gnemon L.) Seed Extract Decreases Serum Uric Acid Levels in Nonobese Japanese Males : A Randomized Controlled Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-483114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483114