The Importance of Velocity Acceleration to Flow-Mediated Dilation
Joint Authors
Young, Joanna M.
Stoner, Lee
Fryer, Simon
Sabatier, Manning J.
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The validity of the flow-mediated dilation test has been questioned due to the lack of normalization to the primary stimulus, shear stress.
Shear stress can be calculated using Poiseuille's law.
However, little attention has been given to the most appropriate blood velocity parameter(s) for calculating shear stress.
The pulsatile nature of blood flow exposes the endothelial cells to two distinct shear stimuli during the cardiac cycle: a large rate of change in shear at the onset of flow (velocity acceleration), followed by a steady component.
The parameter typically entered into the Poiseuille's law equation to determine shear stress is time-averaged blood velocity, with no regard for flow pulsatility.
This paper will discuss (1) the limitations of using Posieuille's law to estimate shear stress and (2) the importance of the velocity profile—with emphasis on velocity acceleration—to endothelial function and vascular tone.
American Psychological Association (APA)
Stoner, Lee& Young, Joanna M.& Fryer, Simon& Sabatier, Manning J.. 2012. The Importance of Velocity Acceleration to Flow-Mediated Dilation. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483117
Modern Language Association (MLA)
Stoner, Lee…[et al.]. The Importance of Velocity Acceleration to Flow-Mediated Dilation. International Journal of Vascular Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-483117
American Medical Association (AMA)
Stoner, Lee& Young, Joanna M.& Fryer, Simon& Sabatier, Manning J.. The Importance of Velocity Acceleration to Flow-Mediated Dilation. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-483117
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483117