Toxoplasma on the Brain : Understanding Host-Pathogen Interactions in Chronic CNS Infection
Joint Authors
Davis, Paul H.
Kamerkar, Sushrut
Source
Journal of Parasitology Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Toxoplasma gondii is a prevalent obligate intracellular parasite which chronically infects more than a third of the world’s population.
Key to parasite prevalence is its ability to form chronic and nonimmunogenic bradyzoite cysts, which typically form in the brain and muscle cells of infected mammals, including humans.
While acute clinical infection typically involves neurological and/or ocular damage, chronic infection has been more recently linked to behavioral changes.
Establishment and maintenance of chronic infection involves a balance between the host immunity and parasite evasion of the immune response.
Here, we outline the known cellular interplay between Toxoplasma gondii and cells of the central nervous system and review the reported effects of Toxoplasma gondii on behavior and neurological disease.
Finally, we review new technologies which will allow us to more fully understand host-pathogen interactions.
American Psychological Association (APA)
Kamerkar, Sushrut& Davis, Paul H.. 2012. Toxoplasma on the Brain : Understanding Host-Pathogen Interactions in Chronic CNS Infection. Journal of Parasitology Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483127
Modern Language Association (MLA)
Kamerkar, Sushrut& Davis, Paul H.. Toxoplasma on the Brain : Understanding Host-Pathogen Interactions in Chronic CNS Infection. Journal of Parasitology Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483127
American Medical Association (AMA)
Kamerkar, Sushrut& Davis, Paul H.. Toxoplasma on the Brain : Understanding Host-Pathogen Interactions in Chronic CNS Infection. Journal of Parasitology Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483127