Intravenous Immunoglobulin in the Management of Lupus Nephritis
Joint Authors
Wenderfer, Scott E.
Thacker, Trisha
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality.
The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses.
Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement.
One approach in the management of patients with lupus nephritis has been the use of intravenous immunoglobulin.
This therapy has shown benefit in the setting of many forms of autoantibody-mediated injury; however, the mechanisms of efficacy are not fully understood.
In this paper, the data supporting the use of immunoglobulin therapy in lupus nephritis will be evaluated.
In addition, the potential mechanisms of action will be discussed with respect to the known involvement of complement and Fc-receptors in the kidney parenchyma.
Results are provocative and warrant additional clinical trials.
American Psychological Association (APA)
Wenderfer, Scott E.& Thacker, Trisha. 2012. Intravenous Immunoglobulin in the Management of Lupus Nephritis. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483135
Modern Language Association (MLA)
Wenderfer, Scott E.& Thacker, Trisha. Intravenous Immunoglobulin in the Management of Lupus Nephritis. Autoimmune Diseases No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-483135
American Medical Association (AMA)
Wenderfer, Scott E.& Thacker, Trisha. Intravenous Immunoglobulin in the Management of Lupus Nephritis. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-483135
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483135