Prognostic Significance of Circulating and Endothelial Progenitor Cell Markers in Type 2 Diabetic Foot
Joint Authors
Paccagnella, Agostino
Furlan, Anna
Gherlinzoni, Filippo
Seganfreddo, Elena
Canal, Fabio
Sambataro, Maria
Niero, Monia
del Pup, Laura
dei Tos, Angelo Paolo
Source
International Journal of Vascular Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
We studied circulating precursor cells (CPC) in type 2 diabetes mellitus (T2DM) with neuropathic foot lesions with or without critical limb ischemia and relationships between endothelial precursor cells (EPC) and peripheral neuropathy.
Methods and Subjects.
We measured peripheral blood CD34, CD133, and CD45 markers for CPC and KDR, CD31 markers for EPC by citofluorimetry and systemic neural nociceptor CGRP (calcitonin gene related protein) by ELISA in 8 healthy controls (C) and 62 T2DM patients: 14 with neuropathy (N), 20 with neuropathic foot lesions (N1), and 28 with neuroischemic recent revascularized (N2) foot lesions.
Timing of lesions was: acute (until 6 weeks), healed, and not healed.
Results.
CD34+ and CD133+ were reduced in N, N1, and N2 versus C, and CD34+ were lower in N2 versus N1 (P=0.03).
In N2 CD34+KDR+ remain elevated in healed versus chronic lesions and, in N1 CD133+31+ were elevated in acute lesions.
CGRP was reduced in N2 and N1 versus C (P<0.04 versus C 26±2 pg/mL).
CD34+KDR+ correlated in N2 with oximetry and negatively in N1 with CGRP.
Conclusions.
CD34+ CPC are reduced in diabetes with advanced complications and diabetic foot.
CD34+KDR+ and CD31+133+ EPC differentiation could have a prognostic and therapeutic significance in the healing process of neuropathic and neuroischemic lesions.
American Psychological Association (APA)
Sambataro, Maria& Seganfreddo, Elena& Canal, Fabio& Furlan, Anna& del Pup, Laura& Niero, Monia…[et al.]. 2014. Prognostic Significance of Circulating and Endothelial Progenitor Cell Markers in Type 2 Diabetic Foot. International Journal of Vascular Medicine،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-483143
Modern Language Association (MLA)
Sambataro, Maria…[et al.]. Prognostic Significance of Circulating and Endothelial Progenitor Cell Markers in Type 2 Diabetic Foot. International Journal of Vascular Medicine No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-483143
American Medical Association (AMA)
Sambataro, Maria& Seganfreddo, Elena& Canal, Fabio& Furlan, Anna& del Pup, Laura& Niero, Monia…[et al.]. Prognostic Significance of Circulating and Endothelial Progenitor Cell Markers in Type 2 Diabetic Foot. International Journal of Vascular Medicine. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-483143
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-483143