The Biological Side of Water-Soluble Arene Ruthenium Assemblies

Abstract EN

This review article covers the synthetic strategies, structural aspects, and host-guest properties of ruthenium metalla-assemblies, with a special focus on their use as drug delivery vectors.

The two-dimensional metalla-rectangles show interesting host-guest possibilities but seem less appropriate for being used as drug carriers.

On the other hand, metalla-prisms allow encapsulation and possible targeted release of bioactive molecules and consequently show some potential as drug delivery vectors.

The reactivity of these metalla-prisms can be fine-tuned to allow a fine control of the guest’s release.

The larger metalla-cubes can be used to stabilize the formation of G-quadruplex DNA and can be used to encapsulate and release photoactive molecules such as porphins.

These metalla-assemblies demonstrate great prospective in photodynamic therapy.